1094598-37-4

Basic information

• Product Name: 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol
• Synonyms: 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol;Venlafaxine N-Oxide;1-[2-Dimethylamino-1-(4-methoxyphenyl) ethyl] cyclohexanol N-oxide
• CAS NO: 1094598-37-4
• Molecular Formula: C₁₇H₂₇NO₃
• Molecular Weight: 322.39934
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Nitric Oxide Reagents;Pharmaceuticals
• Mol File: 1094598-37-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.48±0.20(Predicted)
• CAS DataBase Reference: 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol(1094598-37-4)
• EPA Substance Registry System: 1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol(1094598-37-4)

Safety Data

• Hazardous Substances Data: 1094598-37-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol is used as a prodrug for the antidepressant Venlafaxine (V119995). As a prodrug, it is converted into the active drug in the body, providing a more effective and safer way to deliver the medication.
Used in Antidepressant Treatment:
1-[2-(DiMethyloxidoaMino)-1-(4-Methoxyphenyl)ethyl]cyclohexanol is used as an antidepressant agent for the treatment of various mood disorders, including major depressive disorder, generalized anxiety disorder, and social anxiety disorder. It works by modulating the levels of neurotransmitters in the brain, such as serotonin and norepinephrine, leading to an improvement in mood and overall well-being.

Upstream product

• 93413-69-5 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol 

Downstream Products

• 93413-69-5 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol 

Relevant articles and documents

A chemoselective deoxygenation of N-oxides by sodium borohydride-Raney nickel in water

A simple and convenient protocol for deoxygenation of aliphatic and aromatic N-oxides to the corresponding amines in good to excellent yield using sodium borohydride-Raney nickel in water is reported. Other functional moieties such as alkenes, halides, ethers, and amides are unaffected under the present reaction condition.

N-OXIDES OF VENLAFAXINE AND O-DESMETHYLVENLAFAXINE AS PRODRUGS

Embodiments of the invention relate to a compound of formula (1), or a tautomer, stereoisomer, hydrate, or solvate thereof, wherein R1 is H or CH3. Other embodiments of the invention relate to a pharmaceutical composition containing these compound, to methods for preparing these compounds, and to methods for preparing compositions containing these compounds. Yet other embodiments of the invention relate to the uses of these compounds and compositions containing it, such as for the manufacture of medicaments and pharmaceutical compositions for treating a condition chosen from depression, major depressive disorder, generalized anxiety disorder, obsessive compulsive disorder, social anxiety disorder, panic disorder, general depressive disorders, diabetic neuropathy, migraine and hot flashes.