Major metabolites of Zolpidem: Expeditious synthesis and mass spectra
An expeditious route to the two major metabolites of Zolpidem - and readily applicable to the synthesis of the drug - was established via a cyclization reaction between a 2-aminopyridine and a suitable α-bromoacetophenone. The structures of the target compounds were confirmed from a 2D 1H- 15N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.
Klupsch, Frederique,Houssin, Raymond,Humbert, Luc,Imbenotte, Michel,Henichart, Jean-Pierre,Lhermitte, Michel
p. 1318 - 1321
(2008/09/21)
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