- Synthesis of secondary enamides by ruthenium-catalyzed selective addition of amides to terminal alkynes
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(Chemical Equation Presented) Enamides made easy: A catalyst system generated in situ using bis(2-methallyl)-(cycloocta-1,5-diene)ruthenium(II), 1,4-bis(dicyclohexylphosphino)butane, and ytterbium triflate efficiently catalyzes the addition of primary amides to terminal alkynes, selectively forming the Z-anti-Markovnikov enamides. The E isomers are also accessible by combining the hydroamidation with an in situ double-bond isomerization reaction.
- Goossen, Lukas J.,Salih, Kifah S. M.,Blanchot, Mathieu
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supporting information; experimental part
p. 8492 - 8495
(2009/05/11)
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