109628-27-5 Usage
Uses
Used in Biological Research:
N-(6-Methoxy-8-quinolyl)-4-toluenesulfonamide is used as a selective probe for determining extracellular and intracellular Zn2+ levels in biological systems. Its specificity for Zn2+ allows for accurate measurement and monitoring of zinc ions, which play crucial roles in various cellular processes.
Used in Analytical Chemistry:
In the field of analytical chemistry, N-(6-Methoxy-8-quinolyl)-4-toluenesulfonamide serves as a Zn2+ selective probe, capable of distinguishing between Zn2+ and other metal ions such as Mg2+ and Ca2+. This selective detection is valuable for studying the interactions and roles of these metal ions in various chemical and biological processes.
Used in Pharmaceutical Industry:
N-(6-Methoxy-8-quinolyl)-4-toluenesulfonamide may also find applications in the pharmaceutical industry, potentially as a starting material or intermediate for the synthesis of drugs targeting zinc-related disorders or as a component in drug delivery systems. Its specific interaction with Zn2+ could be exploited to develop targeted therapies or diagnostic tools.
Used in Environmental Science:
In environmental science, N-(6-Methoxy-8-quinolyl)-4-toluenesulfonamide could be employed to monitor and assess the presence of zinc ions in various environmental samples, such as soil, water, and air. This information can be crucial for understanding the impact of zinc pollution and developing strategies for remediation and prevention.
Biochem/physiol Actions
TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline) is a cell penetrant and specific fluorescent zinc sensor that preferentially accumulates in islet cells in a zinc content dependent manner. TSQ is commonly used to assess isolated islet purity.
Check Digit Verification of cas no
The CAS Registry Mumber 109628-27-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,6,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 109628-27:
(8*1)+(7*0)+(6*9)+(5*6)+(4*2)+(3*8)+(2*2)+(1*7)=135
135 % 10 = 5
So 109628-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H16N2O3S/c1-12-5-7-15(8-6-12)23(20,21)19-16-11-14(22-2)10-13-4-3-9-18-17(13)16/h3-11,19H,1-2H3
109628-27-5Relevant articles and documents
NEUROPROTECTIVE QUINOLINE SULFONAMIDES
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Paragraph 0041, (2020/07/07)
Disclosed herein are methods and compositions comprising compounds capable of activating and increasing protein SUMOylation. Disclosed herein are methods and compositions comprising compounds capable of showing neuroprotective and cytoprotective effects w
Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway
Sen, Chiranjit,Sahoo, Tapan,Singh, Harshvardhan,Suresh, Eringathodi,Ghosh, Subhash Chandra
, p. 9869 - 9896 (2019/08/20)
An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.
