Addition of a second binding site increases the dynamic range but alters the cellular localization of a red fluorescent probe for mobile zinc
We report the synthesis and photophysical properties of ZBR4 and ZR1, two resorufin-based ditopic probes for mobile zinc. Upon binding Zn2+, the sensors display 14- and 41-fold enhancements of their red fluorescence emission, respectively. In c
Loas, Andrei,Radford, Robert J.,Lippard, Stephen J.
Fluorinated resorufin compounds and their application
The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compou
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(2010/02/11)
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