109919-32-6

Basic information

• Product Name: 5-Bromo-4-trifluoromethyl-pyridin-2-ol
• Synonyms: 5-Bromo-4-trifluoromethyl-pyridin-2-ol;5-Bromo-2-hydroxy-4-trifluoromethylpyridine;5-Bromo-4-(trifluoromethyl)pyridin-2-ol, 5-Bromo-4-(trifluoromethyl)pyridin-2(1H)-one
• CAS NO: 109919-32-6
• Molecular Formula: C₆H₃BrF₃NO
• Molecular Weight: 241.9933296
• Mol File: 109919-32-6.mol

Chemical Properties

• Boiling Point: 226.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.876±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.71±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-4-trifluoromethyl-pyridin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4-trifluoromethyl-pyridin-2-ol(109919-32-6)
• EPA Substance Registry System: 5-Bromo-4-trifluoromethyl-pyridin-2-ol(109919-32-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 109919-32-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
5-Bromo-4-trifluoromethyl-pyridin-2-ol is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, due to its unique chemical structure and reactivity. Its ability to be incorporated into complex molecules contributes to the development of new drugs and pesticides with enhanced properties.
Used in Chemical Reactions:
5-Bromo-4-trifluoromethyl-pyridin-2-ol is used as a reagent to introduce the pyridine-2-ol functionality into organic molecules. This functionality is important for the synthesis of a wide range of organic compounds, including those with potential applications in material science, pharmaceuticals, and other chemical industries.
Used in Biological Research:
5-Bromo-4-trifluoromethyl-pyridin-2-ol is studied for its potential biological activities, such as its antifungal and antitumor properties. This research is crucial for identifying new therapeutic agents and understanding the compound's mechanism of action, which could lead to the development of novel treatments for various diseases.
Used in the Synthesis of Functional Molecules:
5-Bromo-4-trifluoromethyl-pyridin-2-ol serves as an important intermediate in the production of diverse functional molecules. Its versatility in chemical reactions allows for the creation of molecules with specific properties, which can be applied in various fields, including but not limited to, medicine, agriculture, and material science.

InChI:InChI=1S/C6H3BrF3NO/c7-4-2-11-5(12)1-3(4)6(8,9)10/h1-2H,(H,11,12)

Upstream product

• 50650-59-4 4-(trifluoromethyl)-2-pyridone 

Relevant articles and documents

HETEROCYCLIC WDR5 INHIBITORS AS ANTI-CANCER COMPOUNDS

The present invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; (I) which are inhibitors of WDR5. The present invention also provides pharmaceutical compositions comprising such compounds, compositions comprising such compounds with an additional therapeutic agent and the therapeutic uses of such compounds.

2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure-activity relationships

2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists.

Chemical compounds

Pesticidal compounds of formula (I) wherein R1, R2, R3 and R4 are independently selected from hydrogen, cyano, halogen, lower alkyl optionally substituted by halogen, lower alkoxy optionally substituted by halogen, lower alkenyl optionally substituted by halogen; amino and mono- or di-(lower alkyl) amino;, R6 is oxygen or sulphur;, R7, R8 and R10 are independently selected from hydrogen, halogen, cyano, lower alkyl optionally substituted by halogen, lower alkoxy optionally substituted by halogen, lower thioalkoxy optionally substituted by halo; and, R9 is lower alkyl substituted by halogen or lower alkenyl optionally substituted by halogen. The preparation of these compounds together with their use in combatting insect, acarine and nemotode pests is also described.