- N2-Alkylation of semicarbazones. A general and efficient protocol for the synthesis of 2-alkylsemicarbazides from semicarbazide
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Synthesis of 2-alkylsemicarbazones based on selective N2-alkylation of semicarbazones has been described. The synthesis involves deprotonation of semicarbazones with sodium hydride in MeCN followed by treatment with alkylating reagents. The developed alkylation method was applied to the preparation of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride. This general and efficient protocol is based on preparation of acetone semicarbazone, its alkylation, and hydrolysis under mild conditions.
- Fesenko, Anastasia A.,Trafimova, Ludmila A.,Zimin, Maxim O.,Kuvakin, Alexander S.,Shutalev, Anatoly D.
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p. 176 - 189
(2020/02/13)
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- Cyclization of the semicarbazones to 1,3,4-oxadiazole derivatives using ceric ammonium nitrate as oxidant
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Cyclization of the semicarbazones to 1,3,4-oxadiazole using ceric ammonium nitrate as oxidant was studied. 2-Imino-1,3,4-oxadiazolines can be produced from semicarbazones, which undergo thermolysis to amides. Benzoic acid benzylidene hydrazide can also be cyclized to 2-methoxy-2-phenyl-1,3,4-oxadiazole in the presence of ceric ammonium nitrate and methanol.
- Vahedi,Lari,Bavand,Ameri
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experimental part
p. 288 - 290
(2012/08/08)
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- PYRAZOLOSPIROKETONE ACETYL-C0A CARBOXYLASE INHIBITORS
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The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.
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Page/Page column 37
(2009/12/27)
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- Reactions of diazoalkanes with isocyanates. Synthesis of imidazolidine-2,4-diones, oxindoles, and oxazolidinones
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Thermolysis of a 5,5-dialkyl-Δ3-1,3,4-oxadiazolin-2-one in nitrobenzene containing an aryl isocyanate at 150 deg C affords a 1,3-diaryl-5,5-dialkyl imidazolidine-2,4-dione, an N-arylcarbamoyl-3,3-dialkyloxindole, and a 3-aryl-2-arylimino-5,5-dialkyl-1,3-oxazolidin-4-one.Those products arise from attack of a diazoalkane, generated in situ from the oxadiazolinone by thermal cycloreversion, on the isocyanate function.Two imidazolidine diones, three oxazolidinones, and 14 oxindoles were prepared.
- Fulton, Janet B.,Warkentin, John
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p. 1177 - 1184
(2007/10/02)
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