Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4- tetrahydroisoquinoline analogs
An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethylamines 1 and various aldehydes 2 in the presence of
Thiophenol-mediated improvement of the Pictet-Spengler cyclization of N-tosyl-β-phenethylamines with aldehydes
The Lewis acid-catalyzed Pictet-Spengler condensation of N-tosyl-β-phenethylamines with aldehydes is improved by the addition of thiophenol, furnishing better yields of 1-substituted tetrahydroisoquinolines at a given time.
Silveira, Claudio C.,Vieira, Adriano S.,Kaufman, Teodoro S.
p. 7545 - 7549
(2008/02/08)
Application of the Intramolecular α-Aminoalkylation Reaction for the Synthesis of 2-Arylsulfonyl-1,2,3,4-tetrahydroisoquinolines
The adducts of azomethines and sulfonyl chlorides (Method A) as well as hydroxymethylated sulfonamides (Method B) are used for the synthesis of 2-arylsulfonyl-1,2,3,4-tetrahydroisoquinolines 4a-q.
Lukanov, Ludmil K.,Venkov, Atanas P.,Mollov, Nikola M.
p. 204 - 206
(2007/10/02)
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