- Novel fluorescent isoquinoline derivatives obtained via Buchwald-Hartwig coupling of isoquinolin-3-amines
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Isoquinolin-3-amines bearing an alkyl group or hydrogen atom in position 4 easily underwent Buchwald-Hartwig coupling reactions with various substituted aryl halides. Investigation of the selected new derivatives with fluorescent spectroscopy revealed tha
- Balog, Jozsef,Riedl, Zsuzsanna,Hajos, Gyoergy,Miskolczy, Zsombor,Biczok, Laszlo
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p. 109 - 119
(2013/09/24)
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- Synthesis of 6-methyl-6H-indolo[3,2-c]isoquinoline and 6-methyl-6H-indolo[2,3-c]isoquinoline: two new unnatural isoquinoline isomers of the cryptolepine series
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11H-indolo[3,2-c]isoquinoline has been synthesized in two steps starting from 4-bromoisoquinoline and 2-bromoaniline via a selective Buchwald-Hartwig reaction followed by a Pd-catalyzed intramolecular direct arylation involving C(sp2)-H activation. The synthesis of 7H-indolo[2,3-c]isoquinoline was achieved by a combination of a Suzuki reaction with an intramolecular nitrene insertion reaction starting from 4-bromoisoquinoline and {2-[(2,2-dimethylpropanoyl)amino]phenyl}boronic acid. Selective methylation of the tetracyclic skeletons yielded the title compounds 6-methyl-6H-indolo[3,2-c]isoquinoline and 6-methyl-6H-indolo[2,3-c]isoquinoline, which have never been described in the literature before.
- Van Baelen, Gitte,Meyers, Caroline,Lemière, Guy L.F.,Hostyn, Steven,Dommisse, Roger,Maes, Louis,Augustyns, Koen,Haemers, Achiel,Pieters, Luc,Maes, Bert U.W.
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experimental part
p. 11802 - 11809
(2009/04/11)
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