- Pyrazole compounds as well as preparation method and application thereof
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The invention provides pyrazole compounds with neuraminidase (NA) inhibitory activity as well as a preparation method and application thereof in pharmacy, and specifically relates to a compound shownin a formula (I), and pharmaceutically acceptable salt, an isomer and a prodrug thereof, and the definition of various groups is as described in the description. The invention further relates to pharmaceutic preparations and pharmaceutical compositions of the compounds and application of the pharmaceutic preparations and the pharmaceutical compositions in treatment of diseases caused by influenzavirus infection. The pyrazole compounds provided by the invention have good inhibitory effects on H1N1 influenza A virus infected cells.
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- Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF1) receptor antagonists
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To identify structurally novel corticotropin-releasing factor 1 (CRF 1) receptor antagonists, a series of bicyclic core analogs pyrrolo[1,2-b]pyridazines and pyrrolo[2,1-f]triazin-4(3H)-ones, which were designed based on a monocyclic core antag
- Saito, Tetsuji,Obitsu, Tetsuo,Kohno, Hiroshi,Sugimoto, Isamu,Matsushita, Takeshi,Nishiyama, Taihei,Hirota, Tomoko,Takeda, Hiroyuki,Matsumura, Naoya,Ueno, Sonoko,Kishi, Akihiro,Kagamiishi, Yoshifumi,Nakai, Hisao,Takaoka, Yoshikazu
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experimental part
p. 1122 - 1138
(2012/03/10)
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- Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
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Methods for production of chirally pure α-amino acids and N-sulfonyl α-amino acids are described. An aldehyde and a cyanide salt are reacted with an α-methylbenzylamine to afford product. The product reacts with a strong acid, neutralized, and extracted.
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Page column 21
(2008/06/13)
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- Production of chirally pure alpha-amino acids and N-sulfonyl alpha-amino acids
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Methods for production of chirally pure α-amino acids and N-sulfonyl α-amino acids are described. An aldehyde and a cyanide salt are reacted with an α-methylbenzylamine to afford product. The product reacts with a strong acid, neutralized, and extracted.
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- Heterocyclic sulfonamide inhibitors of beta amyloid production
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Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs there
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