1101120-05-1

Basic information

• Product Name: 3-ForMylpyrazolo[1,5-a]pyridine-5-carbonitrile
• Synonyms: 3-ForMylpyrazolo[1,5-a]pyridine-5-carbonitrile
• CAS NO: 1101120-05-1
• Molecular Formula: C₉H₅N₃O
• Molecular Weight: 171.1555
• Mol File: 1101120-05-1.mol

Chemical Properties

• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.20±0.30(Predicted)
• CAS DataBase Reference: 3-ForMylpyrazolo[1,5-a]pyridine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ForMylpyrazolo[1,5-a]pyridine-5-carbonitrile(1101120-05-1)
• EPA Substance Registry System: 3-ForMylpyrazolo[1,5-a]pyridine-5-carbonitrile(1101120-05-1)

Safety Data

• Hazardous Substances Data: 1101120-05-1(Hazardous Substances Data)

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1101120-00-6 3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate 
• 104468-87-3 pyrazolo [1,5-a]pyridine-5-carboxylic acid 
• 1101120-03-9 pyrazolo[1,5-a]pyridine-5-carboxamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1101118-97-1 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methyl-5-nitrobenzenesulfonohydrazide 
• 1101118-62-0 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)-methylene)-N-(2-hydroxyethyl)-2-methyl-5-nitrobenzenesulfonohydrazide 
• 1101118-71-1 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-methyl-5-nitrobenzenesulfonohydrazide 
• 1101119-63-4 3-((2-methyl-2-(2-methyl-5-nitrobenzyl)hydrazono)methyl)pyrazolo[1,5-a]pyridine-5-carbonitrile 
• 1101118-42-6 5-bromo-N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethylbenzenesulfonohydrazide 
• 1353889-37-8 3-(2-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-1-methylhydrazinylsulfonyl)-4-methylbenzoic acid 
• 1101118-38-0 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-4-nitrobenzenesulfonohydrazide 
• 1101118-48-2 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-(methylsulfonyl)benzenesulfonohydrazide 
• 1353889-39-0 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2,5-trimethylbenzenesulfonohydrazide 
• 1101118-40-4 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-5-fluoro-N,2-dimethylbenzenesulfonohydrazide 
• 1101118-56-2 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-methoxy-N-methyl-5-nitrobenzenesulfonohydrazide 
• 1353889-32-3 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-3-nitrobenzenesulfonohydrazide 
• 1353889-33-4 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-6-nitrobenzenesulfonohydrazide 
• 1353889-34-5 N-(3-(2-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-1-methylhydrazinylsulfonyl)-4-methylphenyl)acetamide 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.

PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY

Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.