- Green, rapid, and highly efficient syntheses of α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones as potentially biologic compounds via solvent-free microwave-assisted Claisen–Schmidt condensation catalyzed by MoCl5
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A new, green, and highly efficient protocol for the expeditious preparation of some α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones via a simple microwave-assisted Claisen–Schmidt condensation reaction catalyzed by MoCl5 was successfully developed. Outstanding features of the current methodology include the use of solvent-free conditions, simple operation, use of a very inexpensive and available catalyst, low catalyst loading, short reaction times, high yields of the pure products, no harmful by-products, easy workup, and also the applicability of microwave irradiation as a clean source of energy. Furthermore, a gram-scale reaction was successfully conducted, proving the scalability of this current Claisen–Schmidt condensation reaction.
- Bakhshi, Reza,Zeynizadeh, Behzad,Mousavi, Hossein
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p. 623 - 637
(2019/08/26)
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- Synthesis and characterization of novel indanone-based spiro-dihydrobenzofuran derivatives
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In this study, the synthesis and characterization of novel indanone-based spiro-dihydrobenzofuran derivatives were examined. Firstly, chalcone-like compounds 4a–k, (E) -2-benzylidene-2,3-dihydro-1 H -inden-1-one derivatives, were synthesized by the base-c
- Güdere, Meliha Burcu,Dürü, Ne?e,Budak, Yakup,Ceylan, Mustafa
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p. 1445 - 1457
(2019/11/02)
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- Michael addition of malononitrile to indenones: Synthesis and characterization of 2-(1-oxo-2,3-dihydro-1H-inden-2-yl) (aryl)(methyl)malononitrile derivatives
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Indanones 3 were prepared from the reaction of indanone (1) with corresponding benzaldehyde derivatives 2, as described in the literature. Then, indenones 3 were subjected to KOtBu-catalyzed Michael addition with malononitrile to give a mixture of diaster
- ?ahin, Betül,Gürdere, Meliha Burcu,Ceylan, Mustafa
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p. 1090 - 1095
(2017/05/25)
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- Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones
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We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.
- Sultan, Aeysha,Raza, Abdul Rauf,Abbas, Muhammad,Khan, Khalid Mohammed,Tahir, Muhammad Nawaz,Saari, Nazamid
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p. 10081 - 10094
(2013/09/23)
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- Rhenium-catalyzed acceptorless dehydrogenative coupling via dual activation of alcohols and carbonyl compounds
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The rhenium hetaphydride complex was found to be a versatile, homogeneous catalyst for dehydrogenative functionalization of alcohol. The dehydrogenative C-C coupling of alcohols and carbonyl compounds was carried out in the absence of base and hydrogen acceptors to afford a series of α,β-unsaturated carbonyl compounds. A possible dual activation pathway was proposed by mechanistic investigations.
- Jin, Hongming,Xie, Jin,Pan, Changduo,Zhu, Zhengbo,Cheng, Yixiang,Zhu, Chengjian
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p. 2195 - 2198
(2013/10/22)
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- Heterocycles. 14. Synthesis of 5H-Indenopyrimidines
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1-Indanone (I) was reacted with aryl aldehydes (II) to give the corresponding 2-arylidene-1-indanones (III).Condensation of the chalcones III with guanidine revealed the formation of the corresponding 5H-2-amino-4-arylidenopyrimidines (V).The structures of all products were substantiated by chemical and spectroscopic methods.
- El-Rayyes, Nizar,Al-Qatami, Sheekha,Edun, Mustafa
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p. 481 - 483
(2007/10/02)
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