Process for the preparation of 2-pyridinecarboxylic acid derivatives and 1-amino-1,4-dihydropyridine-2-carboxylic acid derivatives
The process of the invention relates to the reaction of hydrazones of formula II STR1 with α-chloro- or α-bromoarylonitrile or α-chloro- or α-bromoacrylates of formula III STR2 to 1-amino-2-cyano-1,4-dihydropyridines or 1-amino-1,4-dihydropyridine-2-carboxylic acid esters of formula IV STR3 which are converted into pyridine derivatives of formula I STR4 by treatment with an acid, with removal of R4 R5 NH. Y is --CN or --COOR3 and R1 to R5 may be alkyl.
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(2008/06/13)
A SHORT SYNTHESIS OF FUSARIC ACID AND ANALOGUES
Fusaric acid (5-n-butyl-pyridine-2-carboxylic acid) and other substituted picolinic acid derivatives aresynthesiyed in two steps from readily avaliable α,β/unsaturated hzdrazones and 2-chloroacrylonitrile in high yield.
Waldner, Adrian
p. 2371 - 2374
(2007/10/02)
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