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(2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester is a complex organic compound belonging to the class of Vinca alkaloids. It is characterized by its unique molecular structure, which is primarily determined through spectroscopic data. (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester features a 3α,20-epoxy bridge and a 2-hydroxy group, along with a methyl ester group, contributing to its distinct chemical properties.

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  • (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester

    Cas No: 11034-66-5

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  • (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester

    Cas No: 11034-66-5

  • USD $ 10.0-10.0 / Milligram

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  • 11034-66-5 Structure
  • Basic information

    1. Product Name: (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester
    2. Synonyms: (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester;20-Epimelobaline;20-epi-Melobaline;Vincoline
    3. CAS NO:11034-66-5
    4. Molecular Formula: C21H24 N2 O4
    5. Molecular Weight: 368.4263
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 11034-66-5.mol
  • Chemical Properties

    1. Melting Point: 228-232 °C
    2. Boiling Point: 556°Cat760mmHg
    3. Flash Point: 290.1°C
    4. Appearance: /
    5. Density: 1.42g/cm3
    6. Vapor Pressure: 3.38E-13mmHg at 25°C
    7. Refractive Index: 1.69
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 11.14±0.60(Predicted)
    11. CAS DataBase Reference: (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester(CAS DataBase Reference)
    12. NIST Chemistry Reference: (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester(11034-66-5)
    13. EPA Substance Registry System: (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester(11034-66-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 11034-66-5(Hazardous Substances Data)

11034-66-5 Usage

Uses

Used in Pharmaceutical Industry:
(2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester is used as a pharmaceutical agent for its potential therapeutic effects. Being a Vinca alkaloid, it may exhibit bioactivity against various diseases, particularly cancer, due to the known cytotoxic properties of this class of compounds. Its specific structure, including the epoxy and hydroxyl groups, may contribute to its interaction with cellular targets, leading to potential applications in cancer treatment.
Used in Research and Development:
In the field of scientific research, (2β,5α,12β,19α,20S)-6,7-Didehydro-3α,20-epoxy-2-hydroxyaspidospermidine-3-carboxylic acid methyl ester serves as a valuable compound for studying the structure-activity relationships of Vinca alkaloids. Its unique features can provide insights into the development of new drugs with improved efficacy and reduced side effects. Additionally, it can be used to explore novel mechanisms of action and potential synergistic effects with other therapeutic agents.

References

Aynilian et al.,f. Pharm. Sci., 63536 (1974)

Check Digit Verification of cas no

The CAS Registry Mumber 11034-66-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,3 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 11034-66:
(7*1)+(6*1)+(5*0)+(4*3)+(3*4)+(2*6)+(1*6)=55
55 % 10 = 5
So 11034-66-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H24N2O4/c1-13-18-8-5-10-23-11-9-19(16(18)23)14-6-3-4-7-15(14)22-21(19,25)20(12-18,27-13)17(24)26-2/h3-8,13,16,22,25H,9-12H2,1-2H3/t13-,16-,18-,19+,20-,21-/m0/s1

11034-66-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 20-Epimelobaline

1.2 Other means of identification

Product number -
Other names Vincoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11034-66-5 SDS

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