Effect of fluorination on the pharmacological profile of 11β isomers of fulvestrant in breast carcinoma cells
We describe the synthesis of an 11/β isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11β side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4
Agouridas, Vangelis,Magnier, Emmanuel,Blazejewski, Jean-Claude,La?os, Ioanna,Cleeren, Anny,Nonclercq, Denis,Laurent, Guy,Leclercq, Guy
experimental part
p. 883 - 887
(2009/11/30)
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