Enantioselective bimetallic catalysis of michael additions forming quaternary stereocenters
Robotlike: Low catalyst loadings of a planar-chiral ferrocenyl bispalladacycle are sufficient to catalyze the Michael addition of trisubstituted α-cyanoacetates to enones with excellent yields (TONs up to 2450) and high enantioselectivity. The reaction proceeds by a cooperative bimetallic mechanism and is superior to previous methods relying on soft Lewis acid catalysts. (Chemical Equation Presented)
Jautze, Sascha,Peters, Rene
supporting information; experimental part
p. 9284 - 9288
(2009/05/15)
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