- Novel nucleoside analogues as effective antiviral agents for Zika virus infections
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Previously considered a neglected flavivirus, Zika virus has recently emerged as a public health concern due to its ability to spread rapidly and cause severe neurological disorders, such as microcephaly in newborn babies from infected mothers, and Guilla
- Bassetto, Marcella,Basso, Mattia,Brancale, Andrea,Bugert, Joachim J.,Cima, Cecilia M.,Friese, Daniela,Salerno, Martina,Schwarze, Frank
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Read Online
- METHOD FOR PRODUCING 2-NITROIMIDAZOLE DERIVATIVE
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Disclosed is a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain which is suitable for production of a derivative having a radioisotope. Specifically disclosed is a method for producing 1-(1- benzoyloxymethyl
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Page/Page column 7
(2009/12/23)
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- An efficient synthesis of 2-[(4-amino-1,2-dihydro-2-oxo-1- pyrimidinyl)methoxy]-1,3-propanediyl-di-L-valinate an anti-cytomegalovirus agent
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An efficient synthesis for large scale preparation of the titled compound, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1- (hydroxymethyl)ethoxy)methyl]cytosine, 9, has been developed. The product of each step is easily purified by either distillation o
- Ghali,Johnston,Beauchamp,Naseree,Scott,Flanagan,Rodriguez
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p. 1591 - 1600
(2007/10/02)
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- Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses
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A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.
- Beauchamp, Lilia M.,Serling, Barbara L.,Kelsey, John E.,Biron, Karen K.,Collins, Peter,et al.
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p. 144 - 149
(2007/10/02)
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