1109226-43-8

Basic information

• Product Name: 2-Propyl-5-(pyrimidin-5-yl)thiazole
• Synonyms: 2-Propyl-5-(pyrimidin-5-yl)thiazole
• CAS NO: 1109226-43-8
• Molecular Formula: C10H11N3S
• Molecular Weight: 205.27944
• Mol File: 1109226-43-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propyl-5-(pyrimidin-5-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyl-5-(pyrimidin-5-yl)thiazole(1109226-43-8)
• EPA Substance Registry System: 2-Propyl-5-(pyrimidin-5-yl)thiazole(1109226-43-8)

Safety Data

• Hazardous Substances Data: 1109226-43-8(Hazardous Substances Data)

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 17626-75-4 2-(n-propyl)-thiazole 

Relevant articles and documents

Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides

Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol%) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides. Copyright

Cyclopentyl methyl ether: An alternative solvent for palladium-catalyzed direct arylation of heteroaromatics

Some ethers, such as cyclopentyl methyl ether and di-n-butyl ether, which can be considered as "greener" solvents than N,N-dimethylacetamide (DMAc) or DMF, can be advantageously employed for the palladium-catalyzed direct arylation of heteroaromatics. In the presence of such ethers and only 0.5-1 mol% of palladium catalysts at 125-150°C, the direct 5-arylation of thiazoles, thiophenes, or furans by using aryl bromides as coupling partners proceeds in moderate to high yields.

Palladium-catalysed direct arylations of heteroaromatics using more eco-compatible solvents pentan-1-ol or 3-methylbutan-1-ol

The palladium-catalysed direct coupling of aryl halides with heteroaromatics in greener solvents than DMF or DMAc, which are often employed for such couplings, would be a considerable advantage for both industrial application and sustainable development.