Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
Small molecules that act on multiple biological targets have been proposed to combat the drug resistance commonly observed for cancer chemotherapy. By combining the structural features of known inhibitors of inosine monophosphate dehydrogense (IMPDH) and
Chen, Liqiang,Petrelli, Riccardo,Gao, Guangyao,Wilson, Daniel J.,McLean, Garrett T.,Jayaram, Hiremagalur N.,Sham, Yuk Y.,Pankiewicz, Krzysztof W.
experimental part
p. 5950 - 5964
(2010/10/01)
ANTICANCER AGENTS
The invention provides a compound of the invention, which is a compound of formula A-X-L-B, or a salt thereof, as well as compositions comprising a compound of the invention, and therapeutic methods that include the administration of a compound of the inv
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Page/Page column 32; 33
(2009/03/07)
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