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110932-40-6

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Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors
Abstract A type of novel rhodanine-based 4-anilinoquinazoline, which designed the combination between quinazoline as the backbone and various substituted biological rhodanine groups as the side chain, have been synthesized, and their antiproliferative act
Li, Si-Ning,Xu, Yun-Yun,Gao, Jia-Yu,Yin, Hong-Ran,Zhang, Shi-Lei,Li, Huan-Qiu
p. 3221 - 3227
(2015/08/03)

The Rhodadyns, a new class of small molecule inhibitors of dynamin gtpase activity
Six focused rhodanine-based libraries, 60 compounds in total, were synthesized and evaluated as potential dynamin I GTPase inhibitors. Twenty-six were more potent than the lead compound with 13 returning IC50 values ≤10 μM, making the Rhodadyn
Robertson, Mark J.,Hadzic, Gordana,Ambrus, Joseph,Pome, D. Yuri,Hyde, Emily,Whiting, Ainslie,Mariana, Anna,Von Kleist, Lisa,Chau, Ngoc,Haucke, Volker,Robinson, Phillip J.,McCluskey, Adam
supporting information; experimental part
p. 352 - 356
(2012/06/30)

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Chemical Properties

Density: 1.39g/cm3
PKA: 7.59±0.30(Predicted)
PSA: 93.53000
LogP: 3.68930

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