An efficient synthesis of carbon-14-labeled Saxagliptin (BMS-477118) is described. Initial synthesis of the key radiolabeled intermediate (S)-N-Boc-2-(3′-hydroxyadamantyl)glycine 2a utilized adamantanemethanol in a 10-step sequence. To shorten the sequenc
Cao, Kai,Bonacorsi Jr., Samuel J.,Balasubramanian, Balu,Hanson, Ronald L.,Manchand, Percy,Godfrey Jr., Jollie D.,Fox, Rita,Christopher, Lisa J.,Su, Hong,Iyer, Ramaswamy