DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/ or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.
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Paragraph 0474
(2013/05/08)
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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Page/Page column 114
(2013/05/09)
Cyclic imides; 15. Reaction of 4,5-dichlorophthalimides with potassium nitrite: Synthesis of 4-hydroxy-nitrophthalimides
N-Substituted 4,5-dichlorophthalimides react with potassium nitrite in refluxing dimethylformamide to form N-substituted 4-hydroxy-5-nitrophthalimides.