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CAS

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111265-77-1

(6R,7R)-7-bromo-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 111265-77-1 Structure

  • Basic information

    1. Product Name: (6R,7R)-7-bromo-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one
    2. Synonyms:
    3. CAS NO:111265-77-1
    4. Molecular Formula: C13H16BrN5O5
    5. Molecular Weight: 402.2006
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 111265-77-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 782.5°C at 760 mmHg
    3. Flash Point: 427.1°C
    4. Appearance: N/A
    5. Density: 2.34g/cm3
    6. Vapor Pressure: 8.69E-26mmHg at 25°C
    7. Refractive Index: 1.929
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (6R,7R)-7-bromo-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: (6R,7R)-7-bromo-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one(111265-77-1)
    12. EPA Substance Registry System: (6R,7R)-7-bromo-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-4,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one(111265-77-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 111265-77-1(Hazardous Substances Data)

111265-77-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 111265-77-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,2,6 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 111265-77:
(8*1)+(7*1)+(6*1)+(5*2)+(4*6)+(3*5)+(2*7)+(1*7)=91
91 % 10 = 1
So 111265-77-1 is a valid CAS Registry Number.

111265-77-1Relevant articles and documents

Formation of Six Cyclic 1,N2-Hydroxybromopropanodeoxyguanosine Isomers upon Reaction of 2-Bromoacrolein with 2'-Deoxyguanosine

Meerman, John H.N.,Pearson, Paul G.,Meier, G. Patrick,Nelson, Sidney D.

, p. 30 - 35 (2007/10/02)

As a preliminary study in the investigation of reactions of the genotoxin 2-bromoacrolein (2-BA) with DNA, we treated the aldehyde with 2'-deoxyguanosine (2'-dG).Six isomeric cyclic 1,N2-propano-2'-deoxyguanosine adducts were isolated and characterized by UV, LSIMS, and 1H NMR spectral techniques.The adducts 1a-1d were identified as diastereomeric 3-(2-deoxy-β-D-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-6-hydroxy-7-bromopyrimidopurin-10(3H)-ones.Adducts 2a and 2b were regioisomeric 7-bromo-8-hydroxy diastereomers.At physiological pH (7.4) and temperature (37 deg C), adducts 1a-1d are hydrolyzed to 6,7-dihydroxypropano-2'-de oxyguanosines.These can be transformed to stable 6,7-dihydroxypropanoguanines by removal of the deoxyribose moiety.The resulting bases can be used as standards for further investigations of reactions of 2-BA with DNA.

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