- 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
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The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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Page/Page column 167; 168; 169
(2014/09/29)
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- Synthesis of benzylaminopyrimidines and their fungicidal activities against wheat brown rust and barley powdery mildew
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Members of a new class of fungicide containing benzyl-aminopyrimidine as a core structure were synthesized and their fungicidal potencies against wheat brown rust, Puccinia recondita, and barley powdery mildew, Erysiphe graminis, were assessed. Among these fungicides, N-(fluoroalkoxy or fluorophenoxybenzyl)-4-pyrimidinamines showed notable preventive activities. The potency of the new pyrimidines was increased when a difluoromethoxy or tetrafluorophenoxy group was introduced at the 4- or 3-position of the phenyl moiety and a methyl or ethyl group was introduced at the benzyl position. Structure-activity relationships are discussed.
- Yamanaka,Moritomo,Fujii,Tanaka,Fukuda,Nishimura
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p. 223 - 229
(2007/10/03)
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- Fungicidal composition
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Aralkylamine derivatives, preparation thereof and bactericides containing the sameDisclosed are a fungicidal composition containing a compound represented by the formula (I): wherein R1 represents a halogen atom and R2 and R3 each represent a lower alkyl
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