Development of a practical synthesis of a p38 MAP kinase inhibitor
A practical synthesis of the phthalazine-based p38 MAP kinase inhibitor [(S)-2] was needed for an ongoing program. Vibrational circular dichroism provided the assignment of the absolute stereochemistry of the target compound. The selected synthetic route
Thiel, Oliver R.,Achmatowicz, Michal,Bernard, Charles,Wheeler, Philip,Savarin, Cecile,Correll, Tiffany L.,Kasparian, Annie,Allgeier, Alan,Bartberger, Michael D.,Tan, Helming,Larsen, Robert D.
experimental part
p. 230 - 241
(2010/04/22)
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