The present invention provides novel compositions of matter and processes for their preparation. Particularly, the present invention relates to novel monocyclic β-lactams of formula I, having a carbonyl group, other than a negatively charged group, attached to the N-1 position. The compounds are useful as antimicrobial agents or as intermediates thereto. The present invention also provides a novel process for making these compounds which utilizes palladium (O)--catalyzed carbonylation of an appropriate 2-bromo-1-propen-3-yl amine and novel intermediates prepared by this process.
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(2008/06/13)
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