- PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS
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Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.
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Page/Page column 46-47
(2008/12/07)
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- Novel 21-Aminosteroids That Inhibit Iron-Dependent Lipid Peroxidation and Protect against Central Nervous System Trauma
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A novel class of 21-aminosteroids has been developed.Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC50's as low as 3 μM.Furthermore, selected members enhance early neurolo
- Jacobsen, E. Jon,McCall, John M.,Ayer, Donald E.,VanDoornik, Fred J.,Palmer, John R.,et al.
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p. 1145 - 1151
(2007/10/02)
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