- Peptide deformylase inhibitors
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The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
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Page/Page column
(2014/12/09)
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- PEPTIDE DEFORMYLASE INHIBITORS
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The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity
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Page/Page column
(2014/02/15)
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- SUBSTITUTED AZEPINONE DUAL INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL EXDOPEPTIDASE
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Compounds of the formula STR1 are disclosed as possessing inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
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- Regioselectivity in the Photochemical Ring Contraction of 4-Diazopyrazolidine-3,5-diones to give Aza-β-lactams
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Irradiation of 4-diazopyrazolidine-3,5-diones (15) in the presence of alcohols or water gave mixtures of the isomeric 1,2-diazetidinones (16) and (17), formed by competing photochemical Wolff rearrangement of the two nitrogen groups, followed by reaction of the resulting ketenes with the nucleophile.Some regioselectivity is observed in the ring contraction process, and the relative order of migration of nitrogen groups is NPh>NCHPh2NCH2PhNMe>NCH2CO2Et.The structures of the 1,2-diazetidinones (17c) and (24) were confirmed by X-ray crystallography, and a crystal structure of the diazo compound (15g) was also obtained.Possible reasons for the regioselectivity in the ring contraction are discussed.
- Lawton, Geoffrey,Moody, Christopher J.,Pearson, Christopher J.,Williams, David J.
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p. 885 - 898
(2007/10/02)
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