Welcome to LookChem.com Sign In|Join Free

CAS

  • or

111821-58-0

(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE, also known as (S)-(-)-HA-966, is a chiral organic compound with a unique structure that features an amino group, a hydroxyl group, and a pyrrolidin-2-one ring. It is a potent sedative with ataxic action and is recognized as an NMDA antagonist/partial agonist.

111821-58-0 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 111821-58-0 Structure

  • Basic information

    1. Product Name: (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
    2. Synonyms: (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;(S)-(-)-HA-966;S(-)-HA-966 S(-)-3-AMINO-1-HYDROX;(S)-(-)-3-Amino-1-hydroxypyrrolidine-2-one;(3S)-3-Amino-1-hydroxy-2-pyrrolidinone;(S)-3-Amino-1-hydroxy-2-pyrrolidinone
    3. CAS NO:111821-58-0
    4. Molecular Formula: C4H8N2O2
    5. Molecular Weight: 116.12
    6. EINECS: N/A
    7. Product Categories: Glutamate receptor
    8. Mol File: 111821-58-0.mol

  • Chemical Properties

    1. Melting Point: 166℃
    2. Boiling Point: 259℃
    3. Flash Point: 110℃
    4. Appearance: /
    5. Density: 1.436
    6. Refractive Index: N/A
    7. Storage Temp.: Store at RT
    8. Solubility: N/A
    9. PKA: 7.19±0.20(Predicted)
    10. CAS DataBase Reference: (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE(111821-58-0)
    12. EPA Substance Registry System: (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE(111821-58-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 111821-58-0(Hazardous Substances Data)

111821-58-0 Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE is used as an NMDA antagonist/partial agonist for its sedative and ataxic properties. It plays a crucial role in the development of pharmaceuticals targeting the N-methyl-D-aspartate (NMDA) receptors, which are involved in various neurological conditions and disorders.
Used in Research Applications:
In the field of scientific research, (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE serves as a valuable tool for studying the mechanisms of action and potential therapeutic effects of NMDA receptor modulation. Its use in research helps to advance our understanding of neurological processes and the development of novel treatments for related conditions.

Biological Activity

Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.

Check Digit Verification of cas no

The CAS Registry Mumber 111821-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,8,2 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 111821-58:
(8*1)+(7*1)+(6*1)+(5*8)+(4*2)+(3*1)+(2*5)+(1*8)=90
90 % 10 = 0
So 111821-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m0/s1

111821-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE

1.2 Other means of identification

Product number -
Other names l-a-amino-e-n-benzyl-caprolactam

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:111821-58-0 SDS

111821-58-0Downstream Products

111821-58-0Relevant articles and documents

4-N-Hydroxy-L-2,4-diaminobutyric acid. A strong inhibitor of glutamine synthetase

Fushiya,Maeda,Funayama,Nozoe

, p. 480 - 483 (2007/10/02)

Analogues of glutamic acid were synthesized and evaluated for their inhibitory activity toward glutamine synthetase (EC 6.3.1.2; GS). The title compound, 4-N-hydroxy-L-2,4-diaminobutyric acid (NH-DABA), showed a potent inhibitory activity against GS from

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 111821-58-0