111822-93-6Relevant articles and documents
Derivatives of chrysophanol as topoisomerase II inhibitors
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, (2008/06/13)
The present invention concerns compounds of the formula: STR1 wherein R1 is hydrogen, a hydroxy group or a methoxy group; R2 is hydrogen or a methyl group; R3 is hydrogen or a methyl group; Y is a secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl)2); and Z is hydrogen or a halogen. The invention further provides a method of inhibiting topoisomerase II using a compound having the structure: STR2 wherein R1 is hydrogen, a hydroxy group or a methoxy group; R2 is hydrogen or a methyl group; R3 is hydrogen or a methyl group; Y is a halogen, secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl)2); and Z is hydrogen or a halogen. The invention further concerns pharmaceutical compositions which comprise the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.
Derivatives of chryosphanol
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, (2008/06/13)
The present invention concerns compounds of the formula: STR1 wherein R1 hydrogen, a hydroxyl group or a methoxy group; R2 is hydrogen or a methyl group; R3 is hydrogen or a methyl group; Y is a halogen, a secondary amino group or a tertiary amino group; and Z is hydrogen or a halogen. The invention further concerns pharmaceutical compositions which comprises the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.