- Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions
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Fluoro-substituted aliphatic nitriles are shown to undergo the Houben-Hoesch reactions with arenes in CF3SO3H to give fluoro-substituted ketones in good yields. The fluorine substituents appear to enhance the reactivities of the nitriles (and the nitrilium ion intermediates) compared to similar aliphatic nitriles. Fluoro-substituted ketones are also shown to be accessible through the reactions of organometallic reagents and fluoro-substituted nitriles.
- Raja, Erum K.,Klumpp, Douglas A.
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supporting information; experimental part
p. 5170 - 5172
(2011/10/13)
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- N-Vinylimidazoles and -triazoles and pharmaceutical compositions containing them
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Described are N-vinylazoles of the general formula: (wherein R is hydrogen, hydroxy, halogen, C1-C5 alkoxy, C2-C5 alkenyloxy, optionally substituted benzyloxy, tetrahydropyranyl-oxy, difluoromethoxy, 2-(2,4-dich
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