111861-39-3

Basic information

• Product Name: 2,7-DIAMINO-4-PHENYL-4H-CHROMENE-3-CARBONITRILE
• Synonyms: 2,7-DIAMINO-4-PHENYL-4H-CHROMENE-3-CARBONITRILE;AKOS UB-50088
• CAS NO: 111861-39-3
• Molecular Formula: C₁₆H₁₃N₃O
• Molecular Weight: 263.29
• Mol File: 111861-39-3.mol

Chemical Properties

• Melting Point: 236-237 °C(Solv: ethanol (64-17-5))
• Boiling Point: 515.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 3.76±0.70(Predicted)
• CAS DataBase Reference: 2,7-DIAMINO-4-PHENYL-4H-CHROMENE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-DIAMINO-4-PHENYL-4H-CHROMENE-3-CARBONITRILE(111861-39-3)
• EPA Substance Registry System: 2,7-DIAMINO-4-PHENYL-4H-CHROMENE-3-CARBONITRILE(111861-39-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 111861-39-3(Hazardous Substances Data)

Usage

Chemical Class

Chromene compounds

Nitrogen-containing

Contains two amino groups

Amino groups

Two amino groups attached to the chromene ring

Phenyl group

A phenyl group attached to the chromene ring

Carbonitrile

Indicates the presence of a nitrile group in the molecule

Potential applications

Has potential applications in pharmaceutical research

Biological activity

May exhibit biological activity

Drug development

Could be used in the development of new drugs

Organic synthesis

May be used in organic synthesis

Chemical research

Could be used in chemical research due to its unique structure and reactivity.

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 172475-07-9 3-amino-4-phenyl-7-phenylsulphonamido-4H-benzopyran-3-carbonitrile 

Relevant articles and documents

Synthesis, structure-activity relationship (SAR) studies on some 4-aryl-4H-chromenes and relationship between lipophilicity and antitumor activity

Some 4-aryl-4H-chromenes 3a-h, 5a-g, 7a-g and 9a-g were obtained by reaction of 3-substituted phenol 1,4,6 and 8 with α-cyanocinnamonitrile derivatives 2. We explored the structure activity relationship (SAR) of 4-aryl-4H-chromenes with modification at th

Synthesis of hydroxyquinoline derivatives, amino-hydroxychromene, aminocoumarin and their anti-bacterial activities

Some new diaminochromenes (3a-f, 7a-c, and 10), 7-amino-4-aryl-coumarins (8a,b), 7-hydroxy-4-aryl-1,2-dihydroquinolines (9a-c) and 2-amino-7-hydroxy-4- (4-chlorophenyl)-4H-chromenes (16a-d) were synthesized via Michael addition of different substituted am

Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

SYNTHESIS AND SOME REACTIONS OF NEW BENZOPYRAN DERIVATIVES

Reaction of cinnamonitriles 1a, b with 3-aminophenol (2a) or resorcinol (2b) gave the corresponding benzopyran derivatives (3a-d).Compound (3a) reacted with benzaldehyde to yield monobenzylideneamino derivative 4.Also, reaction of (3a) with benzenesulphonyl chloride gave 2-amino-3-cyano-4-phenyl-7-phenylsulphonylamido-4H-benzopyran (6) which, in turn, underwent some reactions to produce new benzopyranopyrimidine derivatives (7, 9) and (10).Keywords: Synthesis, benzopyrans, sulphonamides, and benzopyranopyrimidines.

CYCLIZATION OF NITRILES. XXIII. ADDITION OF ACTIVE PHENOLS TO ELECTRON-DEFICIENT ETHYLENES, ACCOMPANIED BY CYCLIZAION TO 2-AMINO-4H-BENZOPYRANS. CRYSTAL STRUCTURE OF 2-AMINO-4-(2-FLUOROPHENYL)-3-ETHOXYCARBONYL-4H-NAPHTHOPYRAN

Active phenols and also 2-naphthol react with arylidene derivatives of malononitrile and cyanoacetic ester with the formation of the corresponding substituted 2-amino-4H-benzo- and 2-amino-4H-naphthopyrans.By X-ray crystallographic investigation