Immonium Ion Based Synthetic Methodology: A Novel Method for the N-Methylation of Dipeptides and Amino Acid Derivatives via Retro Aza Diels-Alder Reactions
A novel method for the N-methylation of amino acid derivatives and dipeptides is detailed that features facile room-temperature retro Diels-Alder reactions of N-substituted 2-azanorbornenes with trapping of the incipient immonium ion with triethylsilane/trifluoroacetic acid.
Grieco, Paul A.,Bahsas, Ali
p. 5746 - 5749
(2007/10/02)
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