112018-26-5

Basic information

• Product Name: D-Aspartic Acid diethyl ester hydrochloride
• Synonyms: D-Aspartic Acid diethyl ester hydrochloride;D-Aspartic Acid diet;D-Asp-Oet.2Hcl;(R)-Diethyl 2-aminosuccinate hydrochloride
• CAS NO: 112018-26-5
• Molecular Formula: C₈H₁₅NO₄*ClH
• Molecular Weight: 225.66994
• Product Categories: Amino hydrochloride
• Mol File: 112018-26-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: D-Aspartic Acid diethyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: D-Aspartic Acid diethyl ester hydrochloride(112018-26-5)
• EPA Substance Registry System: D-Aspartic Acid diethyl ester hydrochloride(112018-26-5)

Safety Data

• Hazardous Substances Data: 112018-26-5(Hazardous Substances Data)

Usage

Uses

Used in Athletic Performance Enhancement:
D-Aspartic Acid diethyl ester hydrochloride is used as a supplement for enhancing athletic performance and increasing muscle mass. It is believed to work by promoting the production of testosterone and stimulating the release of growth hormone, which can lead to improved physical performance.
However, it is important to note that there is limited scientific evidence to support the effectiveness of D-Aspartic Acid diethyl ester hydrochloride, and long-term use may pose potential health risks. Therefore, it is crucial to consult with a healthcare professional before using any supplements containing this compound.

Upstream product

• 64-17-5 ethanol 
• 66717-69-9 (R)-Aspartate β-ethyl ester 
• 111934-05-5 D-β-carboxyaspartic acid 
• 911222-16-7 (3R,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<(ethoxycarbonyl)methyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 123098-58-8 (3R,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<(ethoxycarbonyl)methyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 1783-96-6 (2R)-aspartic acid 
• 565461-05-4 (R)-aspartic acid ethyl ester 

Downstream Products

• 111934-09-9 (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionylamino)-succinic acid diethyl ester 
• 428440-11-3 D-Boc-L-Asp(OEt)OEt 

Relevant articles and documents

Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids

The technological utility of active pharmaceutical ingredients (APIs) is greatly enhanced when they are transformed into ionic liquids (ILs). API-ILs have better solubility, thermal stability, and the efficacy in topical delivery than solid or crystalline drugs. However, toxicological issue of API-ILs is the main challenge for their application in drug delivery. To address this issue, 11 amino acid esters (AAEs) were synthesized and investigated as biocompatible counter cations for the poorly water-soluble drug salicylic acid (Sal) to form Sal-ILs. The AAEs were characterized using 1H and 13C NMR, FTIR, elemental, and thermogravimetric analyses. The cytotoxicities of the AAE cations, Sal-ILs, and free Sal were investigated using mammalian cell lines (L929 and HeLa). The toxicities of the AAE cations greatly increased with inclusion of long alkyl chains, sulfur, and aromatic rings in the side groups of the cations. Ethyl esters of alanine, aspartic acid, and proline were selected as a low cytotoxic AAE. The cytotoxicities of the Sal-ILs drastically increased compared with the AAEs on incorporation of Sal into the cations, and were comparable to that of free Sal. Interestingly, the water miscibilities of the Sal-ILs were higher than that of free Sal, and the Sal-ILs were miscible with water at any ratio. A skin permeation study showed that the Sal-ILs penetrated through skin faster than the Sal sodium salt. These results suggest that AAEs could be used in biomedical applications to eliminate the use of traditional toxic solvents for transdermal delivery of poorly water-soluble drugs.

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Practical Asymmetric Syntheses of α-Amino Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine Templates

The optically active D- and L-erythro-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) and D- and L-erythro-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) can be efficiently brominated to serve as electrophilic glycine templates for the asymmetric synthesis of amino acids.It was found that coupling to these templates can proceed with either net retention or net inversion of stereochemistry.The final deblocking to the amino acids is accomplished with either dissolving-metal reduction or catalytic hydrogenolysis.The syntheses of β-ethyl aspartic acid, norvaline, allylglycine, alanine, norleucine, homophenylalanine, p-methoxyhomophenylalanine, cyclopentylglycine, and cyclopentenylglycine and a formal synthesis of clavalanine are described.In addition, the direct asymmetric syntheses of N-t-BOC-allylglycine and N-t-BOC-cyclopentenylglycine are described.

Asymmetric Synthesis of β-Carboxyaspartic Acid

Bromoglycinate 4 was coupled with the (trimethylsilyl)ketene acetal of dibenzyl malonate to furnish predominantly the syn-lactone 6.Hydrogenolysis of 6 directly afforded β carboxyaspartic acid (Asa) in 30percent overall yield in >98percent ee.The optical purity of the synthetic Asa was determined by decarboxylation and esterification to aspartic acid diethyl eester.