METHODOLOGY FOR THE POLYENE AND RELATED ANTIBIOTICS-VERSATILE AND PRACTICAL ACCESS TO BIFUNCTIONAL ALL-TRANS POLYOLEFINIC SYSTEMS
A method is described to assemble all-trans bifunctional polyolefinic chains based on the reaction of aldehydes with a trienic phosphorane developed by Vedejs and coworkers.
Synthesis of ω-Acetyl-α-methylenpolyene Carboxylic Esters
The α-methylenpolyene carboxylic acids 1 and 2 are highly active against Gram-positive bacteria.If this activity arises from an interference with the cell membranes, then an abrupt change in biological properties is to be expected with growing chain length of simple model compounds.To make these tests possible, we describe here the synthesis of a series of homologue esters of type 40.Their synthesis was achieved by Wittig reactions of polyene α,ω-dialdehydes 6 with acetylmethylentriphenylphosphoran 5a and the protected carboxymethylmethylen triphenylphosphonium salt 8.
Laatsch, Hartmut,Pudleiner, Alke
p. 663 - 677
(2007/10/02)
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