cas 112037-78-2, 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE | Articles data ｜lookchem

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112037-78-2

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A Facile Synthesis of 1-Trifluoromethyl-β-carboline
The two-step synthesis of the title compound has been achieved by Mannich-type condensation of tryptamine with trifluoroacetaldehyde, followed by dehydrogenation with selenium dioxide; the overall yield was 79.3percent.
Maki, Yasuo,Kimoto, Hiroshi,Fujii, Shozo
p. 685 - 688
(1987)
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β-Carbolines as specific inhibitors of cyclin-dependent kinases
Harmine (3), 7-fluoro-1-methyl β-carboline (35) and 1-(5-methyl-imidazol-4-yl) β-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases. The degree of aromaticity of the tricyclic ring and the positioning of substituents are important for inhibitory activity. While most β-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) β-carbolines.
Song, Yongcheng,Wang, Jian,Teng, Su Fern,Kesuma, Djohan,Deng, Yu,Duan, Jinao,Wang, Jerry H.,Qi, Robert Zhong,Sim, Mui Mui
p. 1129 - 1132
(2007/10/03)

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Chemical Properties

Melting Point: 147-149°C
Boiling Point: 350 °C at 760 mmHg
Flash Point:165.5 °C
Density: 1.351 g/cm³
PKA: 16.63±0.40(Predicted)
PSA: 27.82000
LogP: 3.24580

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