112100-96-6Relevant articles and documents
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: Synthesis, biological evaluation, and structure - Activity relationships
H?cker, Hans-Georg,Leyers, Stefan,Wiendlocha, Jeanette,Gütschow, Michael,Wiese, Michael
supporting information; experimental part, p. 4586 - 4595 (2010/03/03)
Four series of aromatic carboxylic acids were prepared with a urea or thiourea moiety at the neighboring position to the carboxyl group and benzene or thiophene as aromatic scaffold. Using a calcein AM assay, these compounds were evaluated as inhibitors o
Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase
Gütschow, Michael,Neumann, Ulf
, p. 1729 - 1740 (2007/10/03)
A series of thieno[2,3-d][1,3]oxazin-4-ones was synthesized and evaluated in vitro for inhibitory activity toward human leukocyte elastase. New synthetic routes to 2-alkoxy-, 2-alkylthio-, and 2-sec-amino-substituted derivatives are reported. This study d
The Facile Synthesis of 2-Aminothienothiazin-4-ones, in Some Cases 5,6-Anelated
Leistner, Siegfried,Guetschow, Michael,Wagner, Guenther
, p. 466 - 470 (2007/10/02)
The cyclization of ethyl 2-thioureidothiophene-3-carboxylates is known to give 2-thioxothienopyrimidin-4-ones not only under basic conditions but also upon treatment with ethanolic hydrochloric acid.On the other hand, we have found that ethyl 2-thi
