2-Methyl-1,3-dioxaazaspirodecanes as Novel Muscarinic Cholinergic Agonists
Many nonquaternary ammonium muscarinic agonists have been developed over the last few years, but most of the existing compounds (e.g., arecoline, RS-86, AF-30) behave as weak partial agonists at cholinergic receptors in tissues of limited receptor reserve
Saunders, John,Showell, Graham A.,Snow, Roger J,Baker, Raymond,Harley, Elizabeth A.,Freedman, Stephen B.
PROGRANULIN MODULATORS AND METHODS OF USING THE SAME
Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).
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Paragraph 0362; 0376
(2021/04/30)
HPK1 ANTAGONISTS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
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Paragraph 0844; 0845
(2021/03/19)
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