A Novel Two-Step Synthesis of Hexahydropyrazinoquinolines
The hexahydropyrazinoquinolines 2 were prepared in good yields by reaction of 2-(4-substituted 1-piperazinyl)benzaldehydes 5 with malononitrile and subsequent thermal cyclization of the condensation products 6; the latter reaction takes place via a
Nijhuis, Walter H. N.,Verboom, Willem,Reinhoudt, David N.
p. 641 - 645
(2007/10/02)
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