Structure-activity relationships of N-phenyl-N′-benzothiazol-6-ylurea synthetic derivatives: Cytokinin-like activity and adventitious rooting enhancement
Some years ago we demonstrated the cytokinin-like activity of the synthetic N-phenyl-N′-benzothiazol-6-ylurea (PBU) and a relevant adventitious rooting adjuvant activity of symmetric urea derivatives devoid of any cytokinin- or auxin-like activity per se. Here we report the synthesis and the biological activity evaluation of nine symmetric or asymmetric ureas/thioureas, structurally related to PBU. None of them show cytokinin-like activity, while we demonstrate for the first time that PBU interacts with Arabidopsis cytokinin receptor CRE1/AHK4 in a heterologous bioassay system. Among the PBU derivatives, all the symmetric ureas/thioureas show an adventitious rooting adjuvant activity in various bioassays, confirming that this activity is strictly dependent on their chemical structure.
Rolli, Enrico,Incerti, Matteo,Brunoni, Federica,Vicini, Paola,Ricci, Ada
experimental part
p. 159 - 165
(2012/03/27)
HETEROAROMATIC UREAS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)
Compounds of formula (I): are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).
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Page/Page column 41-42
(2010/02/11)
Synthesis and Reactions of Azido-benzothiazoles and -benzothiophens; Novel Thiazolobenzoxazoles and Dihydrothienobenzoxazoles
6-Azidobenzothiazole and its 2-methyl and 2-methylthio-derivatives were prepared from the corresponding amine and gave the thiazolobenzoxazoles (8)-(10), on thermolysis in a polyphosphoric-acetic acid mixture. 6,7-Dihydro-2-methylthienobenzoxazole 8,8-dioxide (12) was prepared similarly.An improved method of synthesis of 2-fluoro-6-nitrobenzothiazole is reported.
Gallagher, Peter T.,Iddon, Brian,Suschitzky, Hans
p. 2358 - 2361
(2007/10/02)
Synthesis of antimicrobial agents. I. Synthesis and antimicrobial activities of thiazoloquinoline derivatives
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Suzuki,Tanaka,Dohmori
p. 1 - 11
(2007/10/04)
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