- Synthesis method of R-3-methyl closerine hydrochloride
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The invention belongs to the field of drug synthesis, and discloses a synthesis method of R-3-methyl closerine hydrochloride. The synthesis method comprises the following steps: adding D-serine into paraformaldehyde, reacting at room temperature till small volume crystallization to obtain D-erine NCA; adding thionyl chloride into the D-erine NCA in methanol, and after reaction at room temperature,adding petroleum ether to obtain the R-3-methyl closerine hydrochloride. The method is simple in process operation, environmentally-friendly and mild in reaction conditions; the purity of the final product is up to 99 percent, and the yield is up to 94.72 percent, so that industrial production is facilitated.
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Paragraph 0027; 0029; 0030; 0033; 0033; 0035
(2019/05/08)
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