112375-05-0

Basic information

• Product Name: 2-BENZYL-2-AZABICYCLO[2.2.1]HEPT-5-ENE
• Synonyms: 2-BENZYL-2-AZABICYCLO[2.2.1]HEPT-5-ENE;2-AZA-2-BENZYLBICYCLO(2.2.1)HEPT-5-ENE;(1S,4R)-5-Benzyl-5-azabicyclo[2.2.1]hept-2-ene
• CAS NO: 112375-05-0
• Molecular Formula: C₁₃H₁₅N
• Molecular Weight: 185.26
• Mol File: 112375-05-0.mol

Chemical Properties

• Boiling Point: 274.4°C at 760 mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.103g/cm³
• Vapor Pressure: 0.00543mmHg at 25°C
• Refractive Index: 1.608
• PKA: 8.77±0.20(Predicted)
• CAS DataBase Reference: 2-BENZYL-2-AZABICYCLO[2.2.1]HEPT-5-ENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-2-AZABICYCLO[2.2.1]HEPT-5-ENE(112375-05-0)
• EPA Substance Registry System: 2-BENZYL-2-AZABICYCLO[2.2.1]HEPT-5-ENE(112375-05-0)

Safety Data

• Hazardous Substances Data: 112375-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Benzyl-2-azabicyclo[2.2.1]hept-5-ene is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure and functional groups enable the creation of new chemical entities with therapeutic properties, contributing to the development of novel drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, 2-benzyl-2-azabicyclo[2.2.1]hept-5-ene is employed as a versatile building block for the preparation of a wide range of biologically active compounds. Its unique structural features and functional groups allow for the synthesis of diverse chemical entities with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Drug Discovery and Development:
2-Benzyl-2-azabicyclo[2.2.1]hept-5-ene is utilized as a promising candidate in drug discovery and development due to its potential biological and pharmacological activities. Its unique structure and functional groups make it a valuable tool for the design and synthesis of new chemical entities with therapeutic properties, contributing to the advancement of novel treatments for various diseases and conditions.

InChI:InChI=1/C13H15N/c1-2-4-11(5-3-1)9-14-10-12-6-7-13(14)8-12/h1-7,12-13H,8-10H2

Upstream product

• 50-00-0 formaldehyd 
• 3287-99-8 benzylamine hydrochloride 
• 542-92-7 cyclopenta-1,3-diene 

Downstream Products

• 140927-00-0 exo-2-benzyl-2-azabicyclo<2.2.1>heptan-5-ol 
• 46407-10-7 exo-2-benzyl-2-azabicyclo<2.2.1>heptan-6-ol 
• 128862-57-7 N-benzyl-4,4-diphenyl-1,2,4,4a,7,7a-hexahydrocyclopenta-pyridin-3-one 
• 258264-42-5 3-bromo-1-benzyl-1-azoniatricyclo[2.2.1.0^2,6]heptane bromide 

Relevant articles and documents

From cyclopentadiene to isoxazoline-carbocyclic nucleosides: a rapid access to biological molecules through aza-Diels-Alder reactions

A rapid access to carbocyclic nucleosides containing a fused isoxazoline ring is proposed through the Grieco cycloaddition of cyclopentadiene to iminium salts. The prolific elaboration of the isoxazoline cycloadducts allowed preparation of the target amin

Halogenation of 2-alkyl-2-azabicycloalkenes as a method for the synthesis of stable aziridinium salts of a new class

Addition of bromine and potassium dihaloiodates(I) to 2-alkyl-2-azabicyclo[2.2.1]hept-5-enes and 2-alkyl-2-azabicyclo[2.2.2] oct-5-enes affords quaternary ammonium salts containing the aziridine ring and the polyhalide anion. The possibility of using thes

Polysulfones of new structural types as perspective antioxidant agents

A series of polysulfones of new structural types on the basis of azanorbornenes, 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride and tris(diethylamino)diallylaminophosphonium salts were obtained by free radical polymerization reaction. Their antioxidant

Chlorination/cyclodehydration of amino alcohols with SOCl2: An old reaction revisited

(Chemical Equation Presented) A simple, one-pot preparation of cyclic amines via efficient chlorination of amino alcohols with use of SOCl2 has been developed. This approach obviates the need for the classical N-protection/O-activation/cyclization/deprotection sequence commonly employed for this type of transformation. The reaction pathways and the general scope of this method have also been investigated.

A 1,3-Diaza-Claisen rearrangement that affords guanidines

(Chemical Equation Presented) N-Alkyl-N′-tosylthioureas activated by EDCI react with azanorbonenes at room temperature through a 1,3-diaza-Claisen rearrangement, affording highly substituted, bicyclic guanidines in moderate to good yields.

7-oxo-2-azabicyclo[2.2.1]heptanes as selective muscarinic receptor antagonist

The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.

Heterocyclic compounds

The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.

Bridged-diazabicycloalkyl quinolone carboxylic acids and esters

Compounds of the formula and pharmaceutically acceptable acid addition salts thereof, wherein, R1 is hydrogen, (C1-C6)alkyl, or a pharmaceutical-ly acceptable cation;, R2 is ethyl, fluoroethyl, p-fluorophenyl, p-hydroxyphenyl or cycl

ROLE REVERSAL IN THE CYCLOCONDENSATION OF CYCLOPENTADIENE WITH HETERODIENOPHILES DERIVED FROM ARYL AMINES AND ALDEHYDES: SYNTHESIS OF NOVEL TETRAHYDROQUINOLINES

Immonium ions derived from aryl amines and aldehydes function not as heterodienophiles but rather as heterodienes in the presence of cyclopentadiene giving rise to novel tetrahydroquinolines.