112399-51-6Relevant articles and documents
Easy access for the synthesis of 2-aryl 2,3-dihydroquinazolin-4(1H)-ones using gem-dibromomethylarenes as synthetic aldehyde equivalent
Narasimhamurthy, Kereyagalahally H.,Chandrappa, Siddappa,Sharath Kumar, Kothanahally S.,Harsha, Kachigere B.,Ananda, Hanumappa,Rangappa, Kanchugarakoppal S.
, p. 34479 - 34486 (2014)
One step synthesis of 2,3-dihydroquinazolin-4(1H)-ones from gem-dibromomethylarenes using 2-aminobenzamide is described. Gem-dibromomethylarenes are used as aldehyde equivalent for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones, this synthesis takes shorter reaction time with quick isolation and excellent product yield. This journal is the Partner Organisations 2014.
2-Ethynylbenzenealkanamines. A new class of calcium entry blockers
Carson,Almond,Brannan,Carmosin,Flaim,Gill,Gleason,Keely,Ludovici,Pitis,Rebarchak,Villani
, p. 630 - 636 (2007/10/02)
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.