112404-29-2Relevant articles and documents
Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones
González-Chávez, Marco Martín,González-Chávez, Rodolfo,Méndez, Francisco,Martínez, Roberto,Ni?o-Moreno, Perla Del Carmen,Ojeda-Fuentes, Luis Enrique,Richaud, Arlette,Zerme?o-Macías, María de los ángeles
, (2021/08/30)
The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.
Synthesis and cytotoxic activity of new azepino[3′,4′:4,5]pyrrolo[2,1-a]isoquinolin-12-ones
Martinez, Roberto,Arzate, Martha Menes,Ramirez-Apan, Ma. Teresa
experimental part, p. 1849 - 1856 (2009/05/26)
A series of azepino[3′,4′:4,5]pyrrolo[2,1-a]isoquinolin-12-ones (3a-f), that were conformationally restricted analogs of lead compound 2, were designed as potential cytotoxic compounds and synthesized using a radical oxidative aromatic substitution reacti
Tetrahydropyrrolo[3,2-c]azepin-4-ones as a new class of cytotoxic compounds
Martínez, Roberto,ávila, J. Gustavo,Ramírez, Ma. Teresa,Pérez, Araceli,Martínez, ángeles
, p. 4007 - 4016 (2007/10/03)
Pyrroloazepinones 8a-j and 9a-j were designed by structural modification of lead compound 3. These compounds were tested on five tumor cell lines to determine the role of the azeto ring and the 2-methyl substituent in the cytotoxicity of compound 3. Our r
THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 8. THE PAAL-KNORR REACTION WITH CYCLIC 2-(ACYLMETHYL)-2-ALKYL-1,3-DIKETONES: ISOLATION OF 1-ACYL-1H-PYRROLES VIA REARRANGEMENT
Maini, Prem Nath,Sammes, Michael P.,Katritzky, Alan R.
, p. 161 - 168 (2007/10/02)
Treatment of cyclic 2-acylmethyl-2-alkyl-1,3-diketones with ammonium acetate under reflux in acetic acid gives moderate to high yields of 1-acyl-1H-pyrroles by rearrangement.Some of the cyclic diketones react quantitatively with liquid ammonia to yield 2-