1124329-14-1

Basic information

• Product Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
• Synonyms: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one;AZ 3146;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9
• CAS NO: 1124329-14-1
• Molecular Formula: C24H32N6O3
• Molecular Weight: 453
• Product Categories: Inhibitors
• Mol File: 1124329-14-1.mol

Chemical Properties

• Boiling Point: 621.0±65.0 °C(Predicted)
• Appearance: /
• Density: 1.279
• Storage Temp.: Store at +4°C
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
• PKA: 8.29±0.10(Predicted)
• Stability: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• CAS DataBase Reference: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one(1124329-14-1)
• EPA Substance Registry System: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one(1124329-14-1)

Safety Data

• Hazardous Substances Data: 1124329-14-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one is used as a protein kinase Mps1 inhibitor for its potential role in the treatment of various cancers. As a potent and selective inhibitor of Mps1/TTK kinase, it plays a crucial role in the spindle assembly checkpoint, which is essential for proper cell division. By inhibiting this kinase, the compound can disrupt the cell division process, leading to the inhibition of cancer cell growth.
Used in Anticancer Applications:
In the field of oncology, 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one demonstrates its potential as an anticancer agent. It has been shown to decrease the growth of hepatocellular carcinoma in vitro, specifically in SMMC-7721 and BEL-7404 cell lines. The compound's ability to target the Mps1 kinase makes it a promising candidate for further research and development in cancer therapy.
Used in Drug Development and Research:
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one can also be utilized in drug development and research as a lead compound or a chemical probe to investigate the role of Mps1 kinase in various cellular processes. Its structural features and biological activities make it a valuable tool for understanding the underlying mechanisms of cancer cell division and the potential for targeted therapeutic intervention.

References

1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309

Relevant articles and documents

2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS

The invention relates to chemical compounds of the formula (I), or a pharmaceutically acceptable salt thereof, which possess inhibitory activity against the spindle checkpoint kinase: Tyrosine Threonine Kinase (TTK)/monopolar spindle 1 (Mpsl) and are accordingly useful for their anti-cancer effect in a warm-blooded animal such as man. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of a medicament for the treatment of conditions mediated by TTK/Mpsl, for use either alone or in combination with other anti-pro liferative agents.