112448-69-8

Basic information

• Product Name: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one
• Synonyms: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one;1-(1-Oxo-3-phenylpropyl)-1H-pyrrole
• CAS NO: 112448-69-8
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.24842
• Mol File: 112448-69-8.mol

Chemical Properties

• Melting Point: 46-48℃
• Appearance: /
• CAS DataBase Reference: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(112448-69-8)
• EPA Substance Registry System: 3-Phenyl-1-(pyrrol-1-yl)propan-1-one(112448-69-8)

Safety Data

• Hazardous Substances Data: 112448-69-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Phenyl-1-(pyrrol-1-yl)propan-1-one is used as a precursor in the pharmaceutical industry for the synthesis of various drugs and research chemicals. Its unique structure allows for the creation of a wide range of compounds with diverse therapeutic properties.
Used in Organic Chemistry:
In the field of organic chemistry, 3-Phenyl-1-(pyrrol-1-yl)propan-1-one is utilized as a reagent in various chemical reactions. Its versatility in forming different chemical bonds and its compatibility with a range of reaction conditions make it a valuable component in the synthesis of complex organic molecules.
Used in Neurodegenerative Disease Research:
3-Phenyl-1-(pyrrol-1-yl)propan-1-one is used as a research compound in the study of neurodegenerative diseases. Its potential therapeutic applications are being explored, although further research is needed to fully understand its effects and safety profile.
Used in Stimulant Formulations:
Safety Precautions:
Given the potential health and safety hazards of 3-Phenyl-1-(pyrrol-1-yl)propan-1-one, it is crucial to handle this compound with caution. Proper safety measures, including the use of personal protective equipment and adherence to laboratory safety protocols, should be strictly followed to minimize risks.

Upstream product

• 109-97-7 pyrrole 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 55628-83-6 1-(1H-imidazol-1-yl)-3-phenylpropan-1-one 
• 173549-40-1 1-(3-phenylpropanoyl)-2,5-dihydropyrrole 
• 20671-52-7 lithium pyrrolide 

Downstream Products

• 19969-04-1 1-phenyl-heptan-3-one 
• 91119-04-9 5-(2-phenylethyl)-5-nonanol 
• 173549-44-5 1-phenyl-3-(1-pyrrolyl)-3-heptanol 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 850662-61-2 1-(3-phenylpropyl)-1H-pyrrole 
• 497147-46-3 1-(1,3-diphenyl-1-trimethylsilanyloxy-propyl)-1H-pyrrole 
• 1083-30-3 dihydrochalcone 
• 19332-07-1 2,4-diphenyl-butan-2-ol 
• 244091-20-1 (Z)-3-phenyl-1-pyrrolyl-1-trimethylsilyloxyprop-1-ene 

Relevant articles and documents

Structural elucidation and synthesis of new components isolated frompipersarmentosum(piperaceae)

Six components were Isolated from the fruit ofPipersarmentosum. Two of the components are the ubiquitous β-sitosterol and the known unsaturated amide, pellitorine, 3. The other four components, which are new natural products, consist of the aromatic alken

Samarium-mediated intramolecular cross-couplings of an α,β-unsaturated N-acylpyrrole

The first example of an α,β-unsaturated N-acylpyrrole undergoing a SmI2-mediated cyclization is reported. In contrast to other unsaturated units, the intermediate samarium enolate readily engages in aldol-type reactions, necessitating careful control of the reaction conditions.

Remarkably stable tetrahedral intermediates: Carbinols from nucleophilic additions to N-acylpyrroles

Sufficiently stable intermediates formed in the reaction of N-acylpyrroles (1) with hydride and Grignard reagents can undergo further synthetic transformations and chromatographic purification to enable the generation of pyrrolecarbinols 2 in 76-95% yields [Eq. (1)].

Catalytic enantioselective amination of enolsilanes using C2-symmetric copper(II) complexes as chiral lewis acids

(Matrix presented) [Cu(S,S)-t-Bu-box](OTf)2 (1) catalyzes the enantioselective amination of enolsilanes with azodicarboxylate derivatives. Isomerically pure enolsilanes of aryl ketones, acylpyrroles, and thioesters added to the azo-imide in gre

On the Preparation of N-Acylpyrroles and their Use in the Synthesis of Ketones

Two methods for the preparation of N-acylpyrroles have been studied: (a) the reaction between pyrrole and N-acylimidazoles and (b) the oxidation of amides of 3-pyrroline.The reactions between N-acylpyrroles and organolithium compounds can be directed to give ketones in good yields.The initially formed tetrahedral intermediates in these reactions are relatively stable and pyrrolylcarbinols are isolable intermediates.A Reformatsky-Claisen type ring-closure gave a more than doubled yield when an N-acylpyrrole group was used as an electrophile instead of an ester group; the increased stability of the initially formed tetrahedral intermediate presumably accounts for the observed results.