Pd(II)/Cu(II)-Catalyzed Regio- and Stereoselective Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones Using Air as the Terminal Oxidant
Regio- and stereoselective synthesis of (E)-3-arylmethyleneisoindolin-1-ones via Pd(II)/Cu(II)-catalyzed one-pot C-C/C-N bond forming sequence between amides and styrenes is reported. This method provides facile and rapid access to a diverse range of such compounds using readily available starting materials under mild aerobic conditions with good functional group tolerance and high selectivity and efficiency. Further elaboration of the products obtained from this process enabled very short and efficient syntheses of aristolactam and indoloisoquinolinone alkaloids.
Youn, So Won,Ko, Tae Yun,Kim, Young Ho,Kim, Yun Ah
supporting information
p. 7869 - 7874
(2019/01/14)
Synthesis of aristolactam analogues and evaluation of their antitumor activity
A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B
PHENANTHRENE LACTAM DERIVATIVES HAVING ANTICANCER ACTIVITY AND METHOD FOR THE PREPARATION THEREOF
The present invention relates to a phenanthrene lactam derivative having anticanter activity, a method for the preparation thereof, and a pharmaceutical composition comprising same.
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Page/Page column 18-19
(2009/05/28)
Total synthesis of aristolactams via a one-pot Suzuki-Miyaura coupling/aldol condensation cascade reaction
(Chemical Equation Presented) A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki -Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to
Kim, Joa Kyum,Kim, Young Ha,Nam, Ho Tae,Kim, Bum Tae,Heo, Jung-Nyoung
supporting information; experimental part
p. 3543 - 3546
(2009/05/07)
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