- Fused ring non-fullerene acceptors with benzothiophene dioxide end groups and their side chain effect investigations
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The development of small molecule-based non-fullerene acceptors (NF-SMAs) greatly advanced the performances of polymer solar cells (PSCs) in recent years. As the foreseeability of commercializing this technology in the future, interest in reducing the materials cost is rising. To this end, efforts have been made in this work on exploring the usage of commercially available chemical segment of benzothiophene dioxide (BC) in constructing efficient NF-SMAs. Thus, we designed and synthesized two BC-based NF-SMAs, which showed high power conversion efficiency (PCE) of 7.59% also by device engineering and side chain engineering. Our work revealed the full potential of using BC end groups in constructing high-performance NF-SMAs and demonstrated the application of side chain engineering in tuning material properties and performances.
- Deng, Min,Li, Ruipeng,Peng, Qiang,Xu, Xiaopeng,Yu, Liyang
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- Palladium-catalyzed C(sp3)-H arylation of benzo[b]thiophen-3(2H)-one 1,1-Dioxide
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A new concise synthesis route of 2-phenylbenzo[b]thiophen-3(2H)-one 1,1-dioxide from benzo[b]thiophen-3(2H)-one 1,1-dioxide was developed using palladium-catalyzed C(sp3)-H arylation. Compared with the traditional route, this protocol can effec
- Liu, Hailong,Li, Wenjing,Fu, Haiyan,Chen, Hua,Li, Ruixiang,Li, Yu
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- Preparation method of disperse blue 354
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The invention relates to a preparation method of disperse blue 354. The preparation method is characterized by comprising the following steps: preparing a compound Ib, wherein methanol is used as a solvent, with the existence of pyridine, a compound Ia reacts with malononitrile in a mass ratio of 1: (0.4 to 0.5), and the reaction temperature is 45 DEG C to a reflux temperature of the methanol. Byadopting the preparation method, the consumption of malononitrile can be reduced, the reaction condition is mild, harmful substances can be reduced, and a product is good in purity and high in yield.The preparation method is low in initial raw material cost, and high in total yield.
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- Method for preparing aromatic ring[b]thiophene-3(2H)-one-1,1-dioxide
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The invention provides a preparation method of aromatic ring[b]thiophene-3(2H)-one-1,1-dioxide. According to the method, a compound as shown in the formula I reacts with an oxidizing agent to obtain the aromatic ring[b]thiophene-3(2H)-one-1,1-dioxide. The invention also provides a preparation method of the compound as shown in the formula I. The preparation method provided by the invention has thefollowing advantages: reaction yield is high; reaction speed is fast; raw materials are easily available; cost is low; reaction is mild; the method is easy to control; post-treatment is simple; thereare few wastes generated and pollution is low. According to existing methods, synthesis cost is high; post-treatment is cumbersome; there are many ''three wastes'' (wastewater, waste gas and waste residue) in the reaction process and pollution is large, and the yield is low. The method provided by the invention provides a practical and feasible synthetic route for green chemical industry, and hashigh production and application value.
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Paragraph 0050; 0052; 0056
(2019/02/13)
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- INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
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The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.
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- Preparation method of benzo[b] thiophene-3(2H)-keto-1,1-dioxide
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The invention discloses a preparation method of benzo[b] thiophene-3(2H)-keto-1,1-dioxide. The preparation method is characterized by comprising the following steps that a benzoyl acetate solution anda sulfur trioxide solution or a pure liquid sulfur trioxide are continuously pumped into a microchannel reactor for successive and continuous sulfonation reaction and cyclization reaction, the mass flow rate ratio of pumped reaction materials is (0.5-5.0) to 1.0, the temperature of the microchannel reactor is controlled to be 0-80 DEG C, the dwell time of a reaction liquid in the microchannel reactor is controlled to be 1-40min, and the reaction liquid after reaction is finished is subjected to hydrolysis reaction, decarboxylic reaction, solvent recovery, dilution with water, cooling crystallization, filtering, washing and drying to obtain the benzo[b] thiophene-3(2H)-keto-1,1-dioxide. Compared with the traditional technology, the method has the characteristics of continuous reaction, simpleness in operation, high yield, low cost, less three wastes, high safety and the like and has a good industrial prospect.
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Paragraph 0019-0024
(2019/01/13)
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- Indole derivative serving as CRTH2 inhibitor
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The invention discloses an indole derivative serving as a CRTH2 inhibitor shown as a formula (I) as shown in the specification or pharmaceutically acceptable salts, as well as application of the indole derivative in treatment of diseases related to the CR
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- A link and [b] thiophene -3 (2H)-one -1,1-dioxides simple synthesis method of the
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The invention provides a simple method for synthesizing a variety of cyclo[b]thiophene-3(2H)-one-1,1-dioxides from sodium alkyl-sulfinate. The method comprises the following steps: dissolving aromatic cyclic (or heterocyclic) cyano compounds containing ortho halogen substitution and sodium alkyl-sulfinate in proper solvents and using appropriate alkali as an acid binding agent so as to prepare intermediates cyclo[b]thiophene-3(2H)-imine-1,1-dioxides; and hydrolyzing the imine intermediates in an aqueous solution of hydrochloric acid so as to obtain the cyclo[b]thiophene-3(2H)-one-1,1-dioxides. The method provided by the invention has the advantages of easy availability of raw materials, low cost, mild reaction, easy control, simple treatment and applicability to preparation of almost all kinds of cyclo[b]thiophene-3(2H)-one-1,1-dioxides. According to the invention, conventional synthetic methods are optimized, and a novel simple route for synthesis of cyclo[b]thiophene-3(2H)-one-1,1-dioxides is opened up.
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Paragraph 0013-0015
(2018/01/19)
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- Synthetic strategies to 2′-hydroxy-4′- methylsulfonylacetophenone, a key compound for the preparation of flavonoid derivatives
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Different strategies for the synthesis of 2′-hydroxy-4′- methylsulfonylacetophenone are reported in the present paper. This compound is considered as a key synthon for the synthesis of new flavonoid derivatives designed as potential cyclooxygenase-2 inhibitors. The retrosynthetic approach via 3′-methylsulfonylacetophenone, which included three synthetic pathways, did not allow us to obtain the expected compound. However, a synthesis from 3-mercaptophenol led to the desired acetophenone in three steps: thiophenol methylation, Friedel-Crafts acetylation and oxidation of the sulphide to the corresponding sulfone. The desired compound, 2′-hydroxy-4′- methylsulfonylacetophenone, will be used as a synthon for the preparation of novel flavonoid derivatives, such as 2′-hydroxychalcones, flavanones, flavones, and flavonols.
- Gueye, Rokhaya,Pouget, Christelle,Champavier, Yves,Buxeraud, Jacques,Duroux, Jean-Luc,Fagnère, Catherine
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p. 443 - 449
(2014/05/06)
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- Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
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The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing and reacting to its environment. Methods are included for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity or wavelength than when not bound. New fluorophores whose fluorescence responds to environmental changes are also provided that have improved detection and attachment properties, and that can be used in living cells, or in vitro.
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- 2,3-Dihydro-3-oxo-2-phenyliodonium-benzo[b]thiolenide-1,1-dioxide: Synthesis, decomposition and Cu-catalyzed thermal reactions.
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Iodonium ylide 4 was prepared in 93% yield from the reaction of β-ketosulfone 3 with phenyl iodosyl bis(trifluoroacetate). Although insoluble in most solvents, ylide 4 was readily soluble in a mixture of CH2Cl2 ! ethanol (1:1), yield
- Hadjiarapoglou, Lazaros P.,Schank, Kurt
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p. 9365 - 9376
(2007/10/03)
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- DERIVATIVES OF 2-THIOLENE 1,1-DIOXIDE IN THE DIENE SYNTHESIS
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It was shown that derivatives of 2-thiolene 1,1-dioxide have high activity as new dienophiles in the diene synthesis reaction with aliphatic and cyclic 1,3-dienes.The kinetic characteristics were obtained for the reactions of 3-alkylthio-2-thiolen-4-one 1,1-dioxide, 5-benzylidene-2-thiolen-4-one 1,1-dioxide, and 5-benzylidene-3-alkylthio-2-thiolen-4-one 1,1-dioxide with cyclopentadiene.
- Tolstikov, G. A.,Kazakov, V. P.,Shul'ts, E. E.,Bulgakov, R. G.,Kantyukova, R. G.
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p. 278 - 286
(2007/10/02)
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- Reactivity of 2,3-Dihydrobenzothiophene-3-one-1,1-dioxide
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The benzothiophene-1,1-dioxides 2a-d and 3a-c react on warming to 2,3-dihydrobenzothiophene-3-one-1,1-dioxide (1).Compound 1 react with Amines, Hydrazines and Triphenylphosphoranes to give the condensationproducts 4, 7, and 9.With HN3 the Lactam 5 is formed.
- Ried, Walter,Oremek, Gerhard
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p. 619 - 622
(2007/10/02)
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