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CAS

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112708-89-1

(1S,2R)-2-(MethylaMino)-Cyclohexanol, also known as pseudoephedrine, is a chiral compound with the molecular formula C7H15NO. It is commonly used as a decongestant and nasal decongestant in over-the-counter medications. Pseudoephedrine works by shrinking the blood vessels in the nasal passages, which helps to relieve congestion and improve breathing. As a sympathomimetic amine, it acts on the sympathetic nervous system to produce its effects. It is typically administered orally in the form of tablets or capsules and is generally well-tolerated when used as directed.

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  • 112708-89-1 Structure

  • Basic information

    1. Product Name: (1S,2R)-2-(MethylaMino)-Cyclohexanol
    2. Synonyms: (1S,2R)-2-(MethylaMino)-Cyclohexanol;(1S,2R)-2-(Methylamino)cyclohexanol,99%e.e.
    3. CAS NO:112708-89-1
    4. Molecular Formula: C7H15NO
    5. Molecular Weight: 129.2001
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 112708-89-1.mol

  • Chemical Properties

    1. Melting Point: 25-26 °C
    2. Boiling Point: 211.7±33.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 0.97±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 15.03±0.40(Predicted)
    10. CAS DataBase Reference: (1S,2R)-2-(MethylaMino)-Cyclohexanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: (1S,2R)-2-(MethylaMino)-Cyclohexanol(112708-89-1)
    12. EPA Substance Registry System: (1S,2R)-2-(MethylaMino)-Cyclohexanol(112708-89-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 112708-89-1(Hazardous Substances Data)

112708-89-1 Usage

Uses

Used in Pharmaceutical Industry:
(1S,2R)-2-(MethylaMino)-Cyclohexanol is used as a decongestant and nasal decongestant for the treatment of nasal congestion and respiratory issues. It is effective in relieving congestion by constricting the blood vessels in the nasal passages, thus improving breathing.
Used in Over-the-Counter Medications:
(1S,2R)-2-(MethylaMino)-Cyclohexanol is used as an active ingredient in various over-the-counter medications, specifically cold and flu remedies, to provide relief from nasal congestion and other respiratory symptoms.
Note: Due to its potential for abuse and its use in the illicit production of methamphetamine, pseudoephedrine is subject to strict regulations in many countries.

Check Digit Verification of cas no

The CAS Registry Mumber 112708-89-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,7,0 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112708-89:
(8*1)+(7*1)+(6*2)+(5*7)+(4*0)+(3*8)+(2*8)+(1*9)=111
111 % 10 = 1
So 112708-89-1 is a valid CAS Registry Number.

112708-89-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S,2R)-cis-2-(N-methyl)amino-1-cyclohexanol

1.2 Other means of identification

Product number -
Other names (1S,2R)-2-Methylamino-cyclohexanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112708-89-1 SDS

112708-89-1Relevant articles and documents

Resolution of racemic 2-aminocyclohexanol derivatives and their application as ligands in asymmetric catalysis

Schiffers, Ingo,Rantanen, Toni,Schmidt, Frank,Bergmans, Werner,Zani, Lorenzo,Bolm, Carsten

, p. 2320 - 2331 (2007/10/03)

A preparatively easy and efficient protocol for the resolution of racemic 2-aminocyclohexanol derivatives is described, delivering both enantiomers with >99% enantiomeric excess (ee) by sequential use of (R)- and (S)-mandelic acid. A simple aqueous workup procedure permits the isolation of the amino alcohols in analytically pure form and the almost quantitative recovery of mandelic acid. Debenzylation of enantiopure trans-2-(N-benzyl)amino-1- cyclohexanol by hydrogenation and subsequent derivatization give access to a broad variety of diversely substituted derivatives. Furthermore, the corresponding cis isomers are readily available. Applications of these optically active aminocyclohexanols in catalyzed asymmetric phenyl transfer reactions to benzaldehydes and transfer hydrogenations of aryl ketones lead to products with up to 96% ee.

O.N-Bis(diphenylphosphino) Derivatives of Chiral trans- and cis-2-Aminocyclohexanols: Synthesis and Enantioselective Behaviour as Ligands in Rh-based Homogeneous Hydrogenation Catalysts

Pracejus, H.,Pracejus, G.,Costisella, B.

, p. 235 - 245 (2007/10/02)

trans- and cis-2-Methylamino cyclohexanols (MAC) were prepared in enantiomerically pure forms and transformed into O.N-bis(diphenylphosphino) derivatives ("PONP").An analogous trans-1R;2R-aminocyclohexanol PONP could only be isolated in an impure form, whereas the attempted synthesis of PONP's of diastereomeric trans-2-(N-α-phenylethylamino)-cyclohexanols failed.Cationic Rh(I)-chelates of the new PONP's catalyzed the enantioselective hydrogenation of dehydro-α-acylamino acids with /= 97percent ee.A comparison of the enantiodiscriminating properties of the MAC-PONP's with structurally related chiral ligands leads to surprising conclusions.

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