- A three-alkyl (α - alkoxy vinyl) tin synthetic method (by machine translation)
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The invention relates to a three-alkyl (α - alkoxy vinyl) tin synthetic method, is characterized in that the under the protection of nitrogen, the fatty alcohol alkali metal compound, tetramethyl ethylene diamine is dissolved in the hexane, adds by drops positively BuLi hexane solution, then the α - alkoxy vinyl ether dissolved in tetrahydrofuran, in dropping into the mixture, then cooled to - 78 °C; three alkyl tin chloride dissolved with anhydrous in tetrahydrofuran, at this temperature drop in the mixed solution is added, TLC detection reaction, after the reaction is completed in under ice bath adds full and ammonium chloride aqueous solution quenching reaction, the above-mentioned solution is filtered, the filtrate liquid, collecting the organic phase, combined with the organic phase, the organic phase and then sequentially for washing and saturated salt water washing, then filtering the concentrated job to three alkyl (- alkoxy vinyl) tin of the crude product. The invention has the operation is relatively safe, convenient and can be large-scale the advantage of reduced cost. (by machine translation)
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Paragraph 0022; 0023
(2017/01/02)
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- 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
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The invention relates to a compound selected from those of formula (I): STR1 wherein R1, W and Y are as defined in the description, its geometric and/or optical useful as anti-algies.
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- 1-Carba(dethia)cephalosporin antibiotics
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1-Carba(1-dethia)cephem antibacterial agents possessing a 3-(substituted or unsubstituted)thiazolo group are provided. Further provided is a method for treating bacterial infections in man and other animals and a pharmaceutical formulation utilziing said 1-carba(1-dethia)cephems.
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- Stannylated phosphines. I. Preparation of (β-trimethylstannyl)alkyldiphenylphosphines
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(β-Trimethylstannyl)alkyldiphenylphosphines can be readily prepared by addition of diphenylphosphine to the corresponding vinyltrimethyltin Me3SnCR=CH2 under free radical conditions.In contrast, free radical hydrostannation of the corresponding phosphines Ph2PCR=CH2 is a more complex process, and is apparently of little synthetic value.The title compound can be easily oxidised by potassium permanganate to give the corresponding phosphine oxides in good yields.Hydrostannation of model alkynyldiphenylphosphines (RCCPPh2, R=H, Me3Sn) occurs regiospecifically.
- Mitchell, Terence N.,Belt, Heinz-Joachim
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p. 167 - 172
(2007/10/02)
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